栗大超，天津大学精密仪器与光电子工程学院学院教授。从事生物信息学检测技术及仪器领域的研究工作，包括光微流体、声微流体、电化学传感、超声微器件、柔性传感器、喷墨打印微制造等。并且系统开展了生物微流体与生物传感技术在血糖连续监测中的应用研究。
个人经历或学术经历
1.2016年9月至今，天津大学，精密仪器工程系，长聘教授
2.2014年7月至今，天津大学，精密仪器工程系，教授
3.2013年11月至今，天津大学，精密仪器工程系，博士生导师
4.2006年7月至2014年6月，天津大学，精密仪器工程系，副教授
5.2006 年9月至2008年8月，美国凯斯西储大学大学，电子工程与计算机科学系，博士后
6.2004 年7月至2006 年6月，北京大学，微电子学研究院，博士后
7.2004 年4月至2006 年6月，天津大学，精密仪器工程系，讲师
8.1998 年9月至2004 年3月，天津大学，精密仪器及机械专业，博士
9.1994 年9月至1998年6月，天津大学，精密仪器专业，本科
主持科研项目
1.国家自然科学基金面上项目，基于石墨烯金纳米颗粒修饰的亲和型表面等离子共振微葡萄糖传感器。
2.天津市自然科学基金重点项目，金纳米颗粒修饰的亲和型表面等离子共振微葡萄糖传感器。
3.国家自然科学基金海外及港澳学者合作研究基金项目，用于葡萄糖连续检测的亲和型石墨烯纳米传感器。
4.国家自然科学基金外国青年学者研究基金项目，Developments in Additive Microfabrication using Inkjet Printed Gold on Cylindrical Substrates。
5.国家自然科学基金面上项目，细胞间液透皮抽取式血糖连续检测微芯片的研究。
6.国家863计划项目子课题，微创血糖连续检测及胰岛素注入系统的研制。
7.天津市科技支撑计划重点项目，组织液透皮抽取式人体血糖微创监测技术及仪器。
8.教育部促进与美大地区国际合作与高层次人才培养项目，基于纳流控技术的连续血糖检测方法及芯片研究。
9.国家自然科学基金青年教师基金项目，基于人体组织液透皮抽取和分析的微创血糖检测技术。
10.教育部博士学科点青年教师基金项目，基于低频超声和表面等离子共振的微创血糖检测技术。
11.天津市自然科学基金，非采血式人体血糖浓度的微创检测技术研究。
代表性论文
代表性期刊论文
Zhihua Pu, Ridong Wang, Jianwei Wu, Haixia Yu, Kexin Xu andDachao Li*, A flexible electrochemical glucose sensor with composite nanostructured surface on the working electrode, Sensors and Actuators B: Chemical, 2016, 213: 801-809
Dachao Li*, Bingyu Lu, Rui Zhu, Haixia Yu, and Kexin Xu, An optofluidic system with volume measurement and surface plasmon 共振 sensor for continuous glucose monitoring, Biomicrofluidics, 2016,10 (1): 011913 (10 pages)
Zhihua Pu, Chongwei Zou, Ridong Wang, Xiaochen Lai, Haixia Yu, Kexin Xu, andDachao Li*, A continuous glucose monitoring device by graphene modified electrochemical sensor in microfluidic system, Biomicrofluidics,2016,10(1): 011910 (10 pages)
Jianwei Wu, Ridong Wang, Haixia Yu, Guijun Li, Kexin Xu, Norman C. Tien, Robert C. Roberts,Dachao Li*, Inkjet-Printed Microelectrodes on PDMS as Biosensors for Functionalized Microfluidic Systems, Lab on a Chip, 2015, 15: 690-695
Dachao Li*, Songlin Yu, Changyue Sun, Chongwei Zou, Haixia Yu, Kexin Xu, U-shaped fiber-optic ATR sensor enhanced by silver nanoparticles for continuous glucose monitoring, Biosensors and Bioelectronics, 2015,72: 370–375
Dachao Li*, Jianwei Wu, Peng Wu, Yuan Lin, Yingjuan Sun, Yang Jia, Kexin Xu, Affinity Based Glucose Measurement Using Fiber Optic surface PLASMON Resonance Sensor with Surface Modification by Borate 均聚物, Sensors \u0026 Actuators B: Chemical, 2015, 215: 295-304
Dachao Li*, Yanwen Sun, Songlin Yu, Changyue Sun, Haixia Yu, Kexin Xu, A single-loop fiber attenuated total reflection sensor enhanced by silver nanoparticles for continuous glucose monitoring, Sensors and Actuators B: Chemical, 2015, 220: 1033–1042
Dachao Li*, Di Yang, Yang Jia, Yuan Lin, Yingjuan Sun, Haixia Yu, Kexin Xu, Glucose Affinity Measurement by surface Plasmon 共振 with Borate 均聚物 Binding, Sensors and Actuators A: Physical, 2015, 222: 58-66
Dachao Li*, Zhihua Pu, Wenshuai Liang, Tongkun Liu, Ridong Wang, Haixia Yu, Kexin Xu, Non-invasive Measurement of Normal Skin Impedance for Determining the Volume of the Transdermally Extracted Interstitial Fluid, Measurement, 2015, 62: 215-221
Songlin Yu,Dachao Li*, Hao Chong, Changyue Sun, Haixia Yu, Kexin Xu, In Vitro Glucose Measurement Using Tunable Mid-Infrared Laser Spectroscopy Combined with Fiber-Optic Sensor, Biomedical Optics Express, 2014, 5(1): 275-286
Dachao Li*, Xiaoli Zhang, Rui Zhu, Peng Wu, Haixia Yu, Kexin Xu, A Method to Detect the Mixed Petrol Interface by Refractive Index Measurement With a Fiber-Optic SPR Sensor, IEEE Sensors Journal, 2014, 14(10): 3701-3707
Dachao Li*, Ridong Wang, Haixia Yu, Guoqing Li , Yue Sun, Wenshuai Liang, Kexin Xu, A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance Sensor, Sensors, 2014, 14: 7084-7095
Haixia Yu,Dachao Li*, Yongjie Ji, Xiaoli Zhang, Kexin Xu, An interstitial fluid transdermal extraction chip with vacuum generator and volume sensor for continuous glucose monitoring, Key Engineering Materials, 2013, 562-565: 571-575
Songlin Yu,Dachao Li*, Hao Chong, Changyue Sun, Kexin Xu, Continuous Glucose Determination Using Fiber-Based Tunable Mid-Infrared Laser Spectroscopy, Optics and Lasers in Engineering, 2014, 55: 78-83
Ting Shi,Dachao Li*, Guoqing Li, Yuan Lin, Kexin Xu, Luo Lu, Development of A Fluorescent Method for Simultaneous Measurement of Glucose Concentrations in Interstitial Fluid and Blood, Measurement Science and Technology, 2013, 24(12): 125701
Haixia Yu,Dachao Li*, Robert C. Roberts, Kexin Xu, Norman C. Tien, A Micro PDMS Flow Sensor Based on 时间of-Flight Measurement for Conductive 羧基液体丁腈橡胶, Microsystem Technologies, 2013, 19(7): 989-994
Haixia Yu,Dachao Li*, Robert C. Roberts, Kexin Xu, Norman C. Tien, An Interstitial Fluid Transdermal Extraction System for Continuous Glucose Monitoring, Journal of Microelectromechanical Systems, 2012, 21(4): 917-925
Haixia Yu,Dachao Li*, Robert C. Roberts, Kexin Xu, Norman C. Tien, 设计, Fabrication and Testing of A Micro-Venturi Tube for Fluid Manipulation in A Microfluidic System, Journal of Micromechanics and Microengineering, 2012, 22(3) : 035010 (9pp)
Haixia Yu,Dachao Li*, Robert C. Roberts, Kexin Xu, Norman C. Tien, A 时间of-Flight Flow Sensor for the Volume Measurement of Trace Amount of Interstitial Fluid, Journal of Micromechanics and Microengineering, 2012, 22(5) : 055009 (7pp)
代表性国际会议论文
B. Lu, X. Lai, P. Zhang, H. Wu, and D. Li*, “Roughened Cylindrical Gold Layer With Curve Graphene Coating For Enhanced Sensitivity of Fiber SPR Sensor”, IEEE Int. Conf. 固体State Sensors, Actuators and Microsystems (Transducers ’17), June 18-22, 2017, Kaohsiung, Taiwan.
X. Lai, B. Lu, H. Wu, Z. Pu, H. Yu, andD. Li*, “A Novel Method for Generating Monodispersed Droplet Array by Inkjet-Patterned Hydrophilic Symbols for Controlled Reactions”, IEEE Int. Conf. 固体State Sensors, Actuators and Microsystems (Transducers ’17), June 18-22, 2017, Kaohsiung, Taiwan.
Z. Pu, X. Zhang, H. Wu, H. Yu, andD. Li*, “Cylindrical Electrochemical Sensor Fabricated by Rotated Inkjet Printing on Flexible Substrate for Glucose Monitoring”, IEEE Int. Conf. 固体State Sensors, Actuators and Microsystems (Transducers ’17), June 18-22, 2017, Kaohsiung, Taiwan.
Bingyu Lu, Yanwen Sun, Xiaochen Lai, Zhihua Pu, Haixia Yu, Kexin Xu andDachao Li*, Side-polished Fiber SPR Sensor with 温度 Self-compensation for Continuous Glucose Monitoring, The 29th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2016), 24-28 January, 2016, Shanghai, China.
Chongwei Zou, Chengtao Sun, Haixia Yu, Kexin Xu andDachao Li*, Continuous glucose monitoring system based on enzyme colorimetry sensor and microfluidic chip, The 9th International Conference on Advanced Technologies \u0026 Treatments for 糖尿病(ATTD 2016), February 3-6, 2016, Milan, Italy.
Dachao Li*, Changyue Sun, Haixia Yu, Kexin Xu, Fabrication of Silver Nanoparticles on Cylindrical surface of U-Shaped Fiber ATR Sensor by Material 红色uction, The 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015), January 18-22, 2015, Estoril, Portugal.
Dachao Li*, Ridong Wang, Zhihua Pu, Haixia Yu, Kexin Xu, A Gold Nanoparticles-based Electrochemical Sensor in Microfluidic for Continuous Glucose Monitoring, The 8th International Conference on Advanced Technologies \u0026 Treatments for 糖尿病 (ATTD 2015), February 18-21, 2015, Paris, France.
Dachao Li*, Jianwei Wu, Peng Wu, Yuan Lin, Yingjuan Sun, Rui Zhu, Jia Yang, Kexin Xu, Glucose Measurement Using surface Plasmon 共振 Sensor with Affinity based Surface Modification by Borate Polymer, The 18th International Conference on 固体State Sensors, Actuators and Microsystems (Transducers 2015), June 21-25, 2015, Alaska, 南阿拉巴马大学
Dachao Li*, Haixia Yu, Songlin Yu, Peng Wu, Ting Shi, Glucose Continuous Monitoring in Interstitial Fluid by Microfluidic, The 5th International Conference on Optofluidics (Optofluidics 2015), 26-29 July, 2015, Taipei, Taiwan.
Zhihua Pu, Ridong Wang, Haixia Yu, Kexin Xu,Dachao Li*, A Wearable Continuous Glucose Monitoring System with Electrochemical Sensor Modified by Graphene, The 19th International Conference on Miniaturized Systems for 化学 and Life Science (MicroTAS 2015), October 25-29, 2015, Gyeongju, Korea.
Changyue Sun, Yuzhen Cao, Yanwen Sun, Songlin Yu, Haixia Yu*,Dachao Li, Flattened Fiber ATR Sensor Enhanced by Silver Nanoparticles for Continuous Glucose Monitoring, The 19th International Conference on Miniaturized Systems for 化学 and Life Science (MicroTAS 2015), October 25-29, 2015, Gyeongju, Korea.
Chongwei Zou, Chengtao Sun, Haixia Yu, Kexin Xu,Dachao Li*, An Optofluidic System based on Enzyme Colorimetry for Continuous Glucose Monitoring, The 19th International Conference on Miniaturized Systems for 化学 and Life Science (MicroTAS 2015), October 25-29, 2015, Gyeongju, Korea.
Zhihua Pu, Ridong Wang, Haixia Yu, Kexin Xu,Dachao Li*, A Flexible Electrochemical Sensor Modified by Graphene and AuNPs for Continuous Glucose Monitoring, The 14th IEEE SENSORS Conference (IEEE Sensors 2015), November 1-4, 2015, Busan, Korea.
Yanwen Sun, Changyue Sun, Songlin Yu, Haixia Yu*,Dachao Li, Single-Loop Fiber ATR Sensor Enhanced by Silver Nanoparticles for Continuous Glucose Monitoring, The 14th IEEE SENSORS Conference (IEEE Sensors 2015), November 1-4, 2015, Busan, Korea.
Dachao Li*, Ridong Wang, Zhihua Pu, Haixia Yu, Kexin Xu, A Gold Nanoparticles-based Electrochemical Sensor in Microfluidic for Continuous Glucose Monitoring, Advances in Microfluidics and Nanofluidics 2014 Meeting (AMN2014), May 19 to 24, 2014,Taipei,Taiwan.
Jianwei Wu, Robert C. Roberts, Norman C. Tien,Dachao Li*, Inkjet Printed Silver Patterning on PDMS to Fabricate Microelectrodes for Microfluidic Sensing, The 13th IEEE Conference on Sensors (IEEE Sensors 2014), November 2-5, 2014, Valencia, Spain.
Jianwei Wu, Robert C. Roberts, Norman C. Tien,Dachao Li*, Inkjet Printed Microelectrode on PDMS for Manufacturing a Microfluidic Biosensing System, The 4th International Conference on Optofluidics (Optofluidics 2014), August 28-30, 2014, Guangzhou, China.
Dachao Li*and Kexin Xu, Minimally Invasive Glucose Measurement based on Interstitial Fluid Extracted Transdermally, Biomedical Engineering Suzhou International Symposium (BMESIS 2014), April 8-10, 2014, Suzhou, China
Songlin Yu,Dachao Li*, Changyue Sun, Haixia Yu, Kexin Xu , Silver-nanoparticle-enhanced bent fiber-optic ATR sensor combined with tunable mid-infrared laser for glucose measurement, 7th Asia-Pacific Conference on Transducers and Micro/Nano Technologies (APCOT 2014), June 29 – July 2, 2014, Daegu, Korea.
Jianwei Wu, Robert C. Roberts, Norman C. Tien,Dachao Li*, Inkjet Printed Multimetal Microelectrodes on PDMS for Functionalized Microfluidic Systems, The 18th International Conference on Miniaturized Systems for 化学 and Life Sciences (MicroTAS 2014), October 26-30, 2014, San Antonio, USA.
Dachao Li*, Haixia Yu, Jianwei Wu, Di Yang, Yuan Lin, Qian Wang, Kexin Xu, An Optical Lab-on-a-Chip System Based on SPR Sensor for Continuous Glucose Monitoring, The 17th International Conference on Miniaturized Systems for 化学 and Life Sciences (MicroTAS 2013), October 27-31, 2013, Freiburg, Germany.
Dachao Li*, Haixia Yu, Xian Huang, Bing Song, Yuan Jia, Yongjie Ji, Kexin Xu, Qiao Lin, A Microfluidic System with Volume Sensor and Dielectric Glucose Sensor for Continuous Glucose Monitoring, The 17th International Conference on 固体State Sensors, Actuators and Microsystems (Transducers 2013), June 16-20, 2013, Barcelona, Spain.
Dachao Li*, Rui Zhu, Peng Wu, Jianwei Wu, Kexin Xu, Measurement of Glucose Concentration by Fiber-Optic surface PLASMON 共振 Sensor, SPIE Photonics West 2013, February 2-7, 2013, San Francisco, USA.
Dachao Li*, Yang Jia, Peng Wu, Di Yang, Bo Wang, Yuan Lin, Kexin Xu, Glucose Measurement by Surface Plasmon Resonance with Borate Polymer Binding, SPIE Photonics West 2013, February 2-7, 2013, San Francisco, USA.
Dachao Li*, Ridong Wang, Hao Chong, Liu Yu, Kexin Xu, Glucose Measurement in Interstitial Fluid by Microdialysis for the Calibration of Minimally Invasive Blood Glucose Monitoring, SPIE Photonics West 2013, February 2-7, 2013, San Francisco, USA.
Songlin Yu,Dachao Li*, Kexin Xu, Tunable Mid-Infrared Laser Spectroscopy for Glucose Measurement, Conference on Laser Surgery and Medicine 2012 (CLSM 2012), april 25-27, 2012, 横滨市, Japan.
Dachao Li*, Peng Wu, Jia Yang, Rui Zhu, Kexin Xu, An Implantable Fiber-optic surface Plasmon 共振 Glucose Sensor based on TFBG, Conference on laser surgery and medicine 2012 (CLSM 2012), April 25-27, 2012, 横滨市, Japan.
Dachao Li*, Peng Wu, Rui Zhu, Yang Jia, Haixia Yu, Kexin Xu, Implantable Fiber-optic SPR Sensor Modified with LPFG and PAA-ran-PAAPBA for Continuous Glucose Monitoring, The 11th IEEE Sensors Conference (IEEE Sensors 2012), October 28-31, 2012, Taipei, Taiwan.
Dachao Li*, Rui Zhu, Peng Wu, Yang Jia, Kexin Xu, An Implantable Fiber-Optic surface Plasmon 共振 Glucose Sensor Based on LPFG, SPIE Photonics West 2012, January 22-26, 2012, San Francisco, USA.
Ting Shi,Dachao Li*, Yongjie Ji, Guoqing Li , Kexin Xu, Modeling of Relationship between Glucose Concentration in Blood and Glucose Concentration in Interstitial Fluid, SPIE Photonics West 2012, January 22-26, 2012, San Francisco, USA.
Haixia Yu,Dachao Li*, Yongjie Ji, Xiaoli Zhang, Kexin Xu, An Interstitial Fluid Transdermal Extraction Chip with Vacuum Generator and Volume Sensor for Continuous Glucose Monitoring, The 14th Annual Conference of the Chinese Society of Micro/Nano Technology ( CSMNT 2012), November 4-7, 2012, Hangzhou, China.
奖励、荣誉和学术兼职
1.2013年入选教育部“新世纪优秀人才支持计划；
2.2014年获得“教育部技术发明一等奖”；
4.中国高等教育学会测控技术专业委员会委员；
5.天津市便携式医疗电子设备企业重点实验室学术委员会委员。
参考资料
天津大学精密仪器与光电子工程学院教师介绍.天津大学精密仪器与光电子工程学院.2018-10-18