周如鸿
周如鸿，男，舟山定海人，1984年毕业于浙江省舟山中学，1990年周如鸿获浙江大学凝聚态物理硕士学位，后留校任教，1997年获美国哥伦比亚大学博士学位。曾任IBM Watson 研究院软物质科学实验室主任， IBM蓝色基因计划生命科学首席科学家，哥伦比亚大学化学系兼职教授，美国科学促进会院士。现任浙江大学生命科学学院院长、浙江大学上海高等研究院院长、定量生物中心主任、求是讲席教授。
人物经历
教育经历
工作经历
周如鸿教授于2011年当选美国科学促进会会士(美国艺术与科学院 Fellow)，美国物理学会会士(APS Fellow)，并于2012年入选IBM全球八大研究院“将对IBM，对世界，可能产生最重大影响”的五名科学家之一。周如鸿教授同时担任美国分子科学领域顶尖的Telluride科学研究中心董事会的董事（Board of Directors），和芝加哥大学多尺度科学中心的科学顾问（Scientific Advisory Board）。
现任浙江大学求是讲席教授，生命科学院院长，上海高等研究院院长，科技部十四五“生物大分子与微生物”专家组成员，哥伦比亚大学化学系兼职教授。曾任IBM Watson 研究院软物质科学系主任，IBM蓝色基因计划生命科学首席科学家，杰出研究员。
在分子动力学模拟蛋白质结构，功能，以及动态过程、纳米尺度水的生物效应、以及纳米颗粒与生物分子的相互作用等研究领域成就显著。拥有或已申请14项美国专利。在权威学术刊物发表学术论文102篇，SCI引用3200余次。应邀在世界各地大学、研究机构和国际学术会议上做邀请报120余次，是期刊《Nanoscale》、《Current Physical Chemistry》客座主编，也是 《Current Bioinformatics》等6家国际期刊的编委。
代表论文
1. R. H. Zhou, X. Huang, C. Margulius and B. J. Berne, Hydrophobic Collapse in Multi-domain Protein Folding, Science, 305, 1605-1609, 2004
2. P. Liu, X. Huang, R. H. Zhou and B. J. Berne, Observation of a dewetting transition in the collapse of melittin tetramer, Nature, 437, 159-162, 2005
3. L. Cong, R. H. Zhou, Y. C. Kuo, M. Cunniff, and F. Zhang, Comprehensive Interrogation of Natural TALE 脱氧核糖核酸 Binding Modules and Transcriptional Repressor Domains, Nature Commun. 3, 968, 2012
4. Z. Xia, P. Clark, T. Huynh, P. Loher, Y. Zhao, H.W. Chen, P. Y. Ren, I. Rigoutsos, and R. H. Zhou, Molecular 动力学 simulations of Ago silencing complexes reveal a large repertoire of admissible ‘seed-less’ targets, Scientific Reports, 2, 569, 2012
5. S. G. Kang, G. Q. Zhou, P. Yang, Y. Liu, B. Y. Sun, T. Huynh, H. Meng, L. Zhao, G. M. Xing, C. Y. Chen, Y. L. Zhao, R. H. Zhou, Molecular Mechanism of Pancreatic Tumor Metastases Inhibition by Metallofullerenol Gd@C82(OH)22: Implication for de novo 设计 of Nanomedicine, Proc. Natl. Acad. Sci., 109, in press, 2012
6. C. Ge, J. F. Du, L. Zhao, L. Wang, Y. Liu, D. H. Li, Y. Yang, R. H. Zhou, Y. L. Zhao, Z. F. Chai, C. Y. Chen, Binding of human serum proteins on single-wall 碳 nanotubes reduces cytotoxicity, Proc. Natl. Acad. Sci, 108, 16968-16973, 2011 (featured article)
7. P. Das, J. A. King, and R. H. Zhou, Aggregation of ?D-Crystallin Associated with Human Cataracts via Domain Swapping at the C-terminal ?-strands, P世界车王争霸赛 Natl. Acad. Sci. 108, 10514-10519, 2011 (featured article)
8. Y. Tu, P. Xiu, R. Wan, J. Hu, R. H. Zhou and H. Fang, H₂Omediated signal multiplication with Y-shaped 碳 nanotubes, Proc. Natl. Acad. Sci. 106, 18120-18124, 2009
9. L. Hua, R. H. Zhou, D. Thirumalai, B. J. Berne, 尿素 denaturation by stronger dispersion interactions with proteins than H₂O implies a 2-stage unfolding, Proc. Natl. Acad. Sci., 105, 16928-16933, 2008
10. J. Li, X. Gong, H. Lu, D. Li, H. Fang and R. H. Zhou, Electrostatic Gating of a Nanometer Water Channel, Proc. Natl. Acad. Sci., 104, 3687-3692, 2007
11. R. H. Zhou, M. Eleftheriou, A. Royyuru, B. J. Berne, Destruction of long-range interactions by a single mutation in lysozyme, Proc. Natl. Acad. Sci., 104, 5824-5829, 2007
12. R. H. Zhou, Trp-cage: Folding Free 能量 Landscape in Explicit H₂O, Proc. Natl. Acad. Sci., 100, 13280， -13285, 2003
13. R. H. Zhou and B. D. Silverman, Detecting native protein folds among large decoy sets with hydrophobic moments profiling, Proc. Paci. Symp. Biocomp. 2002, Eds. R. B. Altman, A. K. Dunker, L. Hunter, K. Lauderdale and T. E. Klein, p673-684, World Scientific, Singapore, 2002
14. R. H. Zhou, B. J. Berne and R. Germain, Free 能量 landscape of a beta-hairpin folding in explicit H₂O, Proc. Natl. Acad. Sci. 98, 14931-14936, 2001
获奖情况
1. CAREER Award for Researchers “most likely to have the greatest scientific impact for IBM and the world” (at most five scientists chosen each year among eight IBM labs worldwide), IBM Research, May, 2012
2. IBM Outstanding Innovation Award (OIA), IBM Corp. 2012
3. IBM Research Division Award, IBM Research (2012)
4. William E. Schiesser Lecture, Lehigh University, April 2012
5. Elected to AAAS Fellow (American Association of Advancement of Science), 2011
6. Elected to APS Fellow (American Physical Society), 2011
7. Part of the IBM BlueGene Team who won 2009 National Medal on Innovation and Technology (presented by President Obama), 2009
8. IBM Invention Plateau Achievement Award, IBM Corporation (2009)
9. IBM Outstanding Technical Achievement Award (OTAA, the highest technical award of IBM), IBM Corp. (2008)
10. IBM Outstanding 松香酸 Achievement Award (OTAA), IBM Corp. (2005)
11. IBM Research Division Award, IBM Research (2005)
12. IBM Invention Plateau Achievement Award, IBM Corporation (2004)
13. IBM Invention Achievement Award, IBM Corporation (2002)
14. The Hammett Award for Best Ph.D. Graduates, Columbia University (1997)
15. ACS Award on Computational 化学 (DEC Award), American Chemical Society (1995)
16. Faculty Fellowship, Columbia University (1994-1997)
17. Second Prize, Research in Science \u0026 Technology, China Ministry of Education (1993)
18. Best Paper Award for Outstanding Research, Zhejiang University (1993)
19. Award for Outstanding Research, Zhejiang University (1992)
知识产权
1. Bruce J. Berne and Ruhong Zhou, Fast methods for simulating biomolecular systems with long-range electrostatic interactions by molecular 动力学, US patent No. 5,915,230, Jun 22, 1999
2. Ruhong Zhou, Huafeng Xu, Ed Harder, and Bruce J. Berne, System and Method for Molecular Dynamics Simulation , US patent, No. 7,096,167 B2, August 22, 2006
3. Prasanna Athma, Ajay Royyuru, David Silverman and Ruhong Zhou, Method and apparatus for protein structure analysis, US Patent, No. 7,499,805, March 3, 2009
4. Ruhong Zhou, David Silverman, Ajay Royyuru, and Prasanna Athma, Hydrophobic Moment of Multi-domain Proteins, United States, US patent No. 7,877,214, Jan, 25, 2011
5. Ruhong Zhou, David Silverman, Ajay Royyuru, and Prasanna Athma, Hydrophobic Dipole Orientational Analysis for Multi-domain Protein Structures, US patent No. 8,010,332, Jan, 2012
6. Ruhong Zhou, and David Silverman, Method and Apparatus for Protein Structure Analysis, US patent filed (IBM Docket No. YOR920020224US1), Nov. 15, 2002
7. David Silverman, Ruhong Zhou and Ajay Royyuru, Hydrophobic Fourier Transform for Protein Structure Prediction Validation, US patent search (IBM Docket No. YOR820030692), September, 2003
8. Laxmi Parida and Ruhong Zhou, Pattern Discovery Analysis for Protein Folding Trajectories, US patent search (IBM Docket No. YOR820040227), April, 2004
9. Laxmi Parida and Ruhong Zhou, Clustering of Multidimentional Real-valued 数据 Using Signature Patterns, US patent (IBM Docket No. YOR820040321), May, 2004
10. Laxmi Parida and Ruhong Zhou, Visual Analysis of Pattern Landscape 动画, US patent (IBM Docket No. YOR920060233US1), March, 2006
11. Zhen Xia and Ruhong Zhou, Prediction of Influenza A Virus' Genetic Evolution with a Mutual Information Based Site Transition Network, IBM Docket No. YOR820090279, July 1, 2009
12. Payel Das and Ruhong Zhou, A biomimetic nano-pump for automatic separation of urea from H₂O, 解密兄弟 NO. YOR820101155, November 12, 2010
13. Zhen Xia, Tien Hyunh, and Ruhong Zhou, Weighted mutual information method and automatic web server for 流行性感冒 genetic variation prediction, DISCLOSURE NO. YOR820101065, October 18, 2010
14. James Kozloski, Cliff Pickover, Jacinta Wubben and Ruhong Zhou, System and Method for Competitive Binding of Sequence Annotations and Analysis Tools to Sequences in a Biological 数据 Repository, YOR820110975, October, 2011
15. Binquan Luan and Ruhong Zhou, Base-by-base Ratcheting 脱氧核糖核酸 in a Y-shaped 碳 Nanotube, YOR820120589, May, 2012
16. Binquan Luan and Ruhong Zhou, Nanopore-Based Sensors for Detecting Nanotoxicity of a Carbon Nanotube to Proteins, YOR820120951, July, 2012
参考资料
周如鸿 特聘教授.苏州大学医学部放射医学与防护学院.2024-08-17
穿越山海的乡情！——在外舟山人共贺舟山市新闻传媒中心（传媒集团）挂牌成立.微信公众号.2024-08-14
周如鸿 .浙江大学.2024-08-14
周如鸿.浙江大学.2022-01-15